Major congenital malformations are the leading cause of mortality & morbidity in infants of mothers with type 1 or 2 diabetes. Several studies have established an association between elevated maternal glucose or glycated hemoglobin (HbA1C) levels during embryogenesis and high rates of spontaneous abortions. We studied the levels of end glycated proteins in pregnant diabetics with pregnancy induced hypertension (PIH) and the relation of levels of (HbA1C) to fetal and placental blood flow in these patients. Patients with uncontrolled diabetes & PIH showed evidence of affection of placental fetal circulation.