Several methods have been used to identify among healthy neonates those at high risk of developing atopic manifestations If a sensitive method was available that could predict as early as possible, those at high risk of developing atopy, more effective preventive programs could be applied at an early stage.Our aim in this work was to detect the level of interferon gamma in both high and low risk neonates to find a new and accurate method for prediction of atopy.Our study included 20 pregnant women and their full term normal neonates delivered at the obstetric and gynecology department, Kasr El-Einy Hospital. They were divided into two groups. Groups (A) or high risk group which included 10 atopic pregnant women and their neonates. Groups (B) the low risk or normal control group which included 10 non-atopic pregnant women and their 10 neonates with no family history of atopy.