Dialysis associated amyloidosis or β 2 microglobulin- derived amyloidosis is a unique type of amyloidosis that has been described in individuals with ESRD on chronic dialysis. It has been associated with serious complications that significantly add to the morbidity of long term dialysis patients. Its clinical expression in terms of arthralgias, destructive arthropathies and carpal tunnel syndrome is often associated with amyloid deposits, which are mainly composed of β2m fibrils which is related to elevated plasma β 2m that is characteristic of CRF. Also a visceral form with systemic organ involvement has been also described. Diagnosis of DRA is through conventional non invasive diagnostic techniques, i.e. clinical evaluation, joint ultrasonography or X ray, CT or MRI as well as conventional bone scans in addition to scintigraphy with radiolabelled serum amyloid P component (SAP) or with radiolabelled Aβ2m precursor proteinOne of the risk factors that contribute to the development of DRA is the type of HD membranes. High flux dialysis membranes have been shown to remove and adsorb β2m more efficiently than the cellulosic membranes.This study represents a group of 20 CRF patients’ ages between 10-15 years undergoing regular HD in the center of nephrology and kidney transplantation. Blood samples were taken while they were on low flux dialysis membranes to measure the level of β 2 microglobulin in the patients’ sera then they were shifted to high flux dialysis membranes for 3 months and after that period blood samples were withdrawn again to measure and the level of β 2 microglobulin in the sera of these patients to compare them with the previously measured levels. The results of this study showed that the levels were significantly lower on high flux dialysis membranes than on low flux ones.Key words: Chronic renal failure- Dialysis related amyloidosis- Beta 2 microglobulin- Hemodialysis- Membrane flux.