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Relation between insulin level and bone mineral density in patients with type 2 diabetes mellitus

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Internal Medicine

Advisors

Kamal-El-Din, Hebat-Allah M. , Sulttan, Suad E. , El-Tawil, Ahmad E.

Authors

El-Wazir, Amani Kamel Mahmoud

Accessioned

2017-04-26 12:31:29

Available

2017-04-26 12:31:29

type

M.Sc. Thesis

Abstract

Objective: The aim of this work is to measure BMD in patients with type 2diabetes mellitus and to correlate it with insulin level and insulin resistance.Subjects: This study comprised 50 premenopausal women, 40 type 2diabetic patients (20 on insulin therapy and 20 on oral hypoglycemic drugs),10 control group which are healthy non diabetic women matched for age.Methods: All studied subjects were subjected to history taking, clinicalexamination, specially weight, height, BMI and waist/hip ratio andlaboratory investigations including fasting and post prandial blood glucoselevels, HbA1c, kidney functions, liver functions, urine analysis, lipid profile,serum calcium, phosphorus and alkaline phosphatase, fasting insulin level,BMD using DEXA on left fore- arm using Lunar PIXI densitometer .To avoid confounding factors, the following exclusion criteria were enforcedthat all selected subjects must not have other disease that affect bone mineraldensity such as renal impairment, hepatic affection, endocrine diseases thataffect bone density such as thyroid, adrenal disorders and drugs that affectBMD.Results: We found that there is a significant positive correlation betweenBMD with both HOMA and insulin level in patients with type 2 DM.Conclusion: There is no difference in BMD between type 2 diabetic patientsand control group. There is a significant positive correlation between BMDwith both insulin level and insulin resistance (HOMA) in patients with type2 DM.

Issued

1 Jan 2007

DOI

http://dx.doi.org/10.21473/iknito-space/32809

Details

Type

Thesis

Created At

28 Jan 2023