Premature infants frequently suffer from feedingintolerance and are exposed to nasoduodenal feeding andparenteral nutrition with their complications for prolongedtimes. Establishing enteral feeding is therefore a criticalmilestone during management of premature infants.Erythromycin, is a motilin agonist with prokinetic effect whichimprove feeding tolerance however its use should be reservedfor only high risk preterm neonates with persistent and severefeeding intolerance while limiting the duration of exposure andensuring long term follow up.