The aim of the study is to detect Helicobacter pylori seropositivity in females with vomiting (Emesis and Hyperemesis gravidarum) in the first trimester of their ongoing pregnancy in comparison to asymptomatic pregnant females. This study included 60 pregnant women during their first trimester recruited from Kasr El Aini outpatient clinic. They were divided into two groups: Group A: 30 pregnant women with emesis gravidarum ; Group B: 30 healthy pregnant women with no vomiting. Both groups were matched regarding maternal age, gestational age, parity and socioeconomic standard