Objective : Coronary artery ectasia (CAE) is an uncommon angiographic finding and uncommon manifestation of atherosclerosis defined as an arterial segment with a diameter of at least 1.5 times the diameter of the adjacent normal coronary artery. The exact mechanism of its development is unknown; Study was done in an attempt to find an inflammatory etiology in coronary artery ectasia, by measured the serum levels of hs CRP & IL – 6 and correlated to the presence or absence of CAE. Method and results: This study evaluated plasma hs C-reactive protein (CRP) and interleukin-6 (IL-6) levels, as specific markers of inflammation, in 15 patients with coronary artery ectasia (CAE) without stenosis,15 patients with CAE with stenosis and 30 patients with obstructive coronary artery disease without ectasia compared the results with those 15 subjects with angiographically normal coronary arteries. The mean hs CRP levels among the studied groups was 1.1 ± 0.74 ng/dl, 1.2±1.5 ng/dl, 1.5±2.4 ng/dl , 0.33±0.23 ng/dl in group A, B, C and D respectively. The mean IL-6 levels among the studied groups were 5±1.8 pg/dl,4.6±3.55 pg/dl, 4.9±3.7 pg/dl, 2.6±0.61 pg/dl in group A, B, C and D respectively. In comparison of each group with control there is significant P-value, Serum hs CRP and IL-6 levels were found to be significantly higher (P <0.001,0.03,0.01), and (P<0.0001,0.04,0.02) respectively in patients with CAE suggesting that inflammations may be involved in the pathogenesis of CAE. IL-6 levels were 3.3 ± 0.7 pg/dl in patients with one vessel. Lesion, 4.2 ± 1.1 pg/dl in patients with 2 vessels lesion and 6.3 ± 3.8 pg/dl in patients with 3 vessels lesion. (P<0.02). Conclusions: Inflammation plays a major role in the aetiology of CAE as well as coronary artery stenosis. IL-6 and hs CRP as inflammatory markers were elevated in patients with CAE and also were elevated in patients with coronary artery stenosis.IL-6 level was related to the severity of the disease as it was elevated in patients with more vessels affection than in patients with one vessel affection so it could be monitored and used as a severity marker.