Cardiovascular diseases are the leading cause of morbidity and mortality among patients with renal failure. Systemic inflammation caused by renal failure per se and by the process of hemodialysis are important risk factors for cardiovascular disease in this patient population. This study was conducted in order to compare the level of three inflammatory markers: soluble vascular cell adhesion molecule (sVCAM-I) and monocyte chemoattractant protein (MCP-1) and C- reactive protein (CRP) in three different groups of individuals: patients with renal failure on hemodialysis, in patients with renal impairment, and persons without renal impairment. It was also planned to detect the relationship between the level of these markers of inflammation with dialysis adequacy, and nutritional parameters and finally to clarify the relationship between the previously mentioned two markers with the diastolic function and ventricular wall thickness. Our study was conducted on 41 subjects divided into three groups: Group I included 23 patients with end stage renal disease on regular hemodialysis, group II included 10 patients with chronic renal impairment, and group III included 8 normal control subjects. Laboratory tests in the form of urea, creatinine, total protein, serum albumin, cholesterol, triglycerides, serum level of VCAM, MCP-I, and CRP were done for all participants. Dialysis adequacy and post dialysis VCAM-1, MCP-1, and CRP were assessed for group I patients. Echocardiography was done for all patients to determine diastolic function and ventricular wall thickness. In our study, VCAM-1 MCP-1 and CRP levels were significantly higher after the dialysis procedure in patients of group I compared to pre dialysis levels (p< 0.05). Our results have also shown that the blood level of pre-dialysis VCAM-1 was significantly higher in patients on hemodialysis compared to normal controls (p= 0.0001) and to pre ESRD patients. CRP negatively correlated to serum albumin (r -0.43, p0.04). As regards the echocardiographic findings we found that patients with diastolic dysfunction had significantly higher levels of MCP-1.