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Rheumatoid arthritis and macro-vascular disease

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Rheumatology & Rehabilitation

Advisors

El-Surougi, Eiman M. , Muttawea, Seham A. , El-Azizi, Hatem S.

Authors

Ebrahim, Ghada Sayed Abd-Allah

Accessioned

2017-04-26 12:31:26

Available

2017-04-26 12:31:26

type

M.D. Thesis

Abstract

Objective: To measure the extent of subclinical atherosclerosis in patientswith rheumatoid arthritis (RA), and to evaluate any potential vascular riskfactors.Methods: Fifty eight RA patients who were further divided into early andestablished RA patient groups and twenty healthy individuals were includedas a control in this study. Non-invasive vascular tests including; carotidduplex scanning measuring internal carotid and external carotid arteriesintima-media thickness (IMT), and ankle brachial pressure index (ABPI)were performed. Traditional vascular risk factors as blood pressure, bloodsugar, lipids, and steroid usage were assessed.Results: There were significant differences in systolic blood pressure, lipidprofile, and steroid usage between the compared groups. Mean IMT ofcarotid arteries was higher in RA patients group when compared withcontrol group. It was also higher in established than in early RA patients.Carotid plaques appeared in 5 RA patients. Mean IMT was correlatedpositively with patients' age, blood pressure, and disease duration. NeitherRA patients nor controls had abnormal ABPI (<1). Mean ABPI correlatednegatively with mean HAQ score.Conclusion: Increased risk of subclinical vascular diseases in RA patients.Systolic blood pressure, adverse lipid profile, and long-term steroid usagewere of the potential vascular risk factors in RA.

Issued

1 Jan 2007

DOI

http://dx.doi.org/10.21473/iknito-space/32728

Details

Type

Thesis

Created At

28 Jan 2023