Ocular neovascularisation is the primary cause of blidness in a widerange of ocular diseases as diabetic retinopathy central and retinal vein occlusion . It is caused by disturbance of the balance between theangiogenic stimulating factors as VEGF and agiogenic inhibitors.avastin is a new drug which is an anti - VEGF causing inhibition ofangiogenesis and decrease vascular permeability so it is an effectivetreatment for a variety of ocular diseases.