Background and aim: Renal failure is a worldwide public health problem with poor outcomes and high costs. Many factors may be involved in the pathogensis of renal failure as, hypoperfusion, hypoxia, inflammatory responses, and free radical induced renal damage. A drug having pleotropic effects may be of benefit in the treatment of renal failure and the prevention of its progression. Statins (HMG-CO A reductase inhibitors) posses this character. Objectives: This experimental study was designed to evaluate the effect of atorvastatin and fluvastatin on kidney function in normal rats and in those with acute kidney injury induced by ischemia reperfusion, as well as in chronic renal damage induced by cyclosporine.Material and methods: Male adult albino rats weighing 190-210g were used. To induce acute kidney injury, rats were subjected to bilateral renal ischemia for 45 minutes followed by reperfusion for 24 hours. Another group received atorvastatin in a dose of 10mg/kg for 15 days before induction of acute kidney injury. Atorvastatin was also administered to normal rats group to act as control. To induce chronic renal damage, rats received cyclosporine intraperitoneally in a dose of 10mg/kg/day for 28days. Atorvastatin or fluvastatin were administered on day one of induction of cyclosporine chronic renal damage for 28 days in doses of 10 and 20 mg/kg/day orally respectively. Normal rats received atorvastatin and fluvastatin for 28 days to act as control groups. At the end of the experiment, the following parameters were measured in serum: urea and creatinine, albumin, cystatin C, potassium, total cholesterol, triglycerides and creatinine phosphokinase (CPK). In addition, the right kidneys were removed to asses superoxide dismutase (SOD) tissue content. Histopathological examination of the kidneys was performed in the different groups.Results: normal rats that received atorvastatin and fluvastatin showed insignificant changes of all the measured parameters, except CPK, which showed a significant elevation in the groups treated for 28 days. Serum urea and creatinine, cystatin C, potassium, total cholesterol and triglycerides were elevated and tissue SOD and serum albumin were decreased in both the ischemia reperfusion injury model and the cyclosporine induced chronic renal failure model. Treatment with atorvastatin and fluvastatin decreased the elevated levels of these parameters and improved the decreased levels of albumin and SOD. The marked histopathological changes induced by ischemia reperfusion and cyclosporine were ameliorated in rats treated by atorvastatin and fluvastatin.Conclusion: The obtained data of the present study showed that atorvastatin and fluvastatin improved the renal damage caused by ischemia reperfusion and cyclosporine administration suggesting the possibility of nephroprotection in both acute and chronic renal damage.