Non-Hodgkin lymphomas are heterogeneous group ofmalignancies of B- and T-cells that arise from lymphoid tissue. Theyexhibit varied clinical and biological features. B-cell lymphomas make upthe majority of cases. The purpose of the current study was detecting theeffect of the genetic polymorphism of the oxidative stress genes andconcomitant HCV infection on B-cell NHL risk in Egypt. The presentstudy included 100 newly diagnosed NHL patients and 100 healthycontrols. Genotyping for oxidative stress genes was done by PCR-RFLPtechnique and screening for HCV infection was performed by reversetranscriptase polymerase chain reaction (RT-PCR). The study revealedthat MPO-G463A homotype (AA) and GPX1 mutant genotypes;heterotype (PL) and homotype (LL) can be considered as risk factor forNHL. Also, there is strong association of HCV infection with the risk ofdeveloping NHL in Egypt.