Chronic renal failure is characterized by a persistently abnormal glomerular filtration rate. It represents a developing process that is initiated by various causes; Renin angiotensin system may affect chronic kidney disease (CKD) through induction of tissue growth and fibrosis.This study was to evaluate the association of AT1R gene (A1166C) polymorphism as one of the RAS gene family, with chronic renal failure (CRF). This association was evaluated to shed light on pathophysiology of CRF and identify risk assessmentAC genotype frequency of AT1R gene (A1166C) was higher in CRF patients group versus control group (p =0.056). AC was significantly higher in hypertensive than normotensive (p =0.00).