Background: Skin tags are dermatological lesions commonly found in the general population and have been associated with diabetes mellitus, obesity, impaired carbohydrate metabolism, insulin resistance, impaired lipid metabolism and atherosclerosis. Early detection of patients with atherosclerosis may play an important preventive role. However, there still is a need for clinical studies to evaluate the atherogenic risk factors in patients with ST.Aim of work: To find if there is relation between skin tags and cardiovascular risk factorsPatient and methods: This study was done on 30 patients with skin tags; 30 cardiac patients with skin tags and 30 healthy controls. All patients and controls were subjected to clinical examination in which height, weight, body mass index, waist circumference and blood pressure were measured. Also serum level of homocysteine, endothelin-1 and high sensitive CRP was done by HPLC and ELISA techniques, whereas lipid profile and fasting blood sugar were measured using regular laboratory methods.Results: In this study it was found that serum level of homocysteine, endothelin-1, high sensitive CRP and association of metabolic syndrome were significantly higher in patients with skin tags than control but still significantly lower than the level in cardiac patients with skin tags. However the difference serum level of triglycerides, cholesterol and fasting blood sugar were non significant between patients with skin tags and cardiac patients. Conclusion: Follow-up of patients with skin tags (specially those with dark ST) as regards the development of diseases associated with atherosclerosis may be beneficial as ST frequently associated with obesity, hypertension, dyslipidemia, diabetes mellitus.