Urinary calculi are the third prevalent disorder in urinary system. Approximately, 80% of these calculi composed of calcium oxalate (Ca Ox), and calcium phosphate. hyperoxaluria causing renal cell damage and free radical production which augmente crystal deposition in the renal tubules. Nigella sativa and Hajrul yahood were mentioned in folklore medicine in treatment of renal stone disease. Antioxidant & anti-inflammatory effects of nigella sativa were speculated that of the roles of the Ns in preventing formation of CaOx calculi. Hajrul yahood had lithotriptic and diuretic effects which may explain his role in treatment of renal calculi. The aim of this study is to investigate the effects of Nigella sativa seeds and Hajrul yahood bahsma on renal calculi induced by ethylene glycol in male albino rats.