The use of solvents in paint industry entails different health hazards to the workers. One of the most important hazards is the cytogenetic changes that can lead into cancer on the long term.This study aimed at minimizing the gap in our knowledge concerning the cytogenetic effects due to exposure to mixture of solvents in the paint industry, and used an interventional way for minimizing those hazards through the use of antioxidants and studying their protective role.The 78 workers were recruited into the current study from a paint factory divided into 2 groups: exposed group (39 workers exposed to organic solvents) and control group (39 non exposed workers), all the workers were subjected to full clinical and occupational history and examination in addition to measurement and follow-up of chromosomal aberrations and sister chromatids.Our data suggest that workers in paint industry are exposed to a mixture of different solvents that can collectively cause cytogenetic changes in the form of increased frequencies of CA and SCE above normal limits, especially with long durations of exposure. Also, the study indicates the great importance for administration of antioxidants on a regular basis to counteract the cytogenetic impacts of solvents on workers in paint industry and its protective role against cancer vulnerability in those workers.