Patients with severe critical limb ischemia (CLI) due to tibial disease are often poor candidates for surgical revascularization and frequently end up with a lower limb amputation. Tibial angioplasty offers a minimally invasive alternative for limb salvage in this patient population. Aim of the study was to compare the results of angioplasty of one vessel versus more than one vessel in patients with CLI due to tibial disease. Methods: we retrospectively reviewed all consecutive patients with tibial disease with no concomitant proximal lesions who were treated by angioplasty. A total of 48 procedures in 48 patients (29 males and 19 females; mean age, 63.2 ± 10.5 [SD] years) were evaluated. Results: limb salvage rate was 85.4%. A major amputation was needed in 3 limbs (1 below-knee amputation and 2 above-knee amputations). 3 patients (6.3%) died during follow-up. Conclusion: In our selected patient population with ischaemic diabetic foot and isolated BTK lesions, limb salvage rate was the same in patients who had single vessel angioplasty and patients who had more than one vessel angioplasty.