Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) that produces demyelination and axonal/neuronal damage, resulting in characteristic multifocal lesions on magnetic resonance imaging (MRI) and a variety of neurologic manifestations, which first develops in young adults as acute relapses, and then evolve into a gradually progressive course with permanent disability after 10–15 years. Optic neuritis (ON) is a common clinical manifestation of MS characterized by acute onset of visual acuity (VA) loss often accompanied by visual field loss, color desaturation, and pain with eye movement. Although most patients' VA recovers to baseline after an episode of ON, residual deficits in contrast sensitivity are common.