This study was done to assess the serum level of ACE and plasma level of angiotensin II in patients with chronic liver disease and to correlate these levels with the degree of portal hypertension, the presence of ascites and renal function.This study included 59 patients (40 males and 19 females) and 19 healthy age and sex matched controls. Patients with post hepatitic chronic liver disease were included in this study and were; 16 patients with uncomplicated chronic liver disease (group A), 11 patients with liver cirrhosis and portal hypertension without ascites (group B), 21 patients with portal hypertension and ascites (group C) and 11 patients with hepatorenal syndrome (group D). Patients were subjected to full medical history and clinical examination, abdominal ultrasonography, upper endoscopy with grading of oesophagogastric varices, laboratory evaluation including liver and kidney function tests, creatinine clearance, serum and urinary electrolytes, in addition to assessment of plasma level of angiotensin II by radioimmunoassay (RIA) and serum level of ACE by kinetic method. It was found that the mean values of serum ACE and plasma angiotensin II increased significantly from group A to D and it was found that their values in group B and group C were nearly similar but were higher than group A. Values in group D were higher than other groups. There was significantly negative correlation between the values of ACE and angiotensin II and each of blood pressure, serum sodium, urinary sodium, urinary creatinine and creatinine clearance. On the other hand, there was significantly positive correlation between the values of ACE and angiotensin II and each of PV diameter, grade of varices, degree of ascites, serum creatinine, blood urea and serum bilirubin, while the highly significantly positive correlation was between serum ACE and plasma angiotensin II values and between their values and Child Pough classification and this indicates that their values increase with the severity of liver disease.