This study includes 50 cases, 45 cases of CRC (colorectal carcinoma) and 5 cases of normal colon collected from surgical colectomy specimens. Immunohistochemical staining of VEGF (vascular endothelial growth factor) and p53 was done using the streptavidin-biotin technique. This thesis consisted of introduction, aim of the work, review of literature, material and methods, results, discussion, conclusions, recommendations and references, together with a summary in English and another in Arabic. This work reveals that both VEGF and p53 are positive in most of CRC and negative in normal colon with a statistically significant relation between staining of both markers. This proves the correlation between p53 and the expression of VEGF and thus between p53 and angiogenesis in CRC; material antagonizing this might have a role in treatment.