The hepatitis C virus (HCV) epidemic in Egypt is unique in theworld and well documented in the international medical scientificliterature. We described a wide range of central and peripheralnervous system disorders linked to HCV infection by clinical,laboratory, neurophysiological and imaging. Since there is HCVepidemic in Egypt that is unique in the world and well documentedin the international medical scientific literature, hence HCV-relatedneurological complications should be included in the differentialdiagnosis of cryptogenic neurological disorders in Egyptianpatients.