Objective: The aim of this study is to evaluate the clinico-pathological profile of the bronchogenic carcinoma cases in the department of chest Medicine of Cairo University Hospital.Material and Methods: This retrospective study was carried out in the department of chest Medicine of Cairo University Hospital, in which four hundred and four (404 cases) confirmed cases of bronchogenic carcinoma were included in this study. These patients were admitted during the last 10 years. Data regarding demographics, smoking , histology, clinical presentation, radiographic findings, The method of diagnosis and stage of the disease were obtained from their files.Results: Our study included 404 of confirmed cases of bronchogenic carcinoma. Male to female ratio was 4.6:1. The highest incidence of bronchogenic carcinoma was in the sixth and seventh decades of life (63.6 %). the majority of cases occur in the age >40 years (94.1 %) while in age <40 years, the incidence was 5.9 % . The smoking was found to be the main risk factor in 75.7% patients. The cough was the most common symptom found in 347 patients (85.9 %), followed by dyspnea in 276 patients ( 68.3%). The most common radiological finding was mass lesion (49.8%). The majority of cases were diagnosed by fibro-optic bronchoscopy (68.1 % of all cases). Four types of bronchogenic carcinoma were found: squamous cell carcinoma 37.4%, adenocarcinoma 29.5%, small cell carcinoma 14.9%, large cell carcinoma 7.2% and undifferentiated carcinoma 11.1 % . In females, a denocarcinoma was the predominant cell type (54.2%) while in males, a squamous cell carcinoma was predominant cell type (42.5%). Most cases were diagnosted in late stages of the diaease.Conclusion: Bronchogenic carcinoma is more frequent beyond the middle age. It is more frequent in males than females. Smoking still the major risk factors in pathogenesis of bronchogenic carcinoma . Adenocarcinoma is more common in females and was the most frequent tumour in non-smokers. while in males, a squamous cell carcinoma still the predominant cell type.