Airways hyperresponsiveness can occur as solitary evidence of airwaysdysfunction. Because hyperresponsiveness is associated with the presenceand severity of disease, it is important to measure and quantitate airwaysresponsiveness. The most useful challenge procedure appears to be themethacholine challenge, not so much because it offers the best specificity ofthe challenge procedures but because it has been characterized well.The aim of this observational cross- sectional study is to assess thebronchial hyperresponsiveness in children with intermittent asthma and mildto moderate persistent. Twenty five patients participated in the study allwere subjected to methacoline challenge test (MCT), skin prick test, totalserum IgE and measurement of peripheral blood eosinophil count. Wedetected 40% of patients showed BHR. The mean concentration ofmethacoline at which the test was discontinued is 6.11±3.3 mg. There was astatistically significant correlation between IgE and eosinophilia andbetween PC20 and age of the patients. We found no statistical significancebetween BHR and the following: skin test, IgE, eosinophilia and the severityof the disease.