Purpose: To assess the relationship between macular thickness overall and in each of nine regions and the axial length in myopes.Patients and Methods: Forty eyes of twenty myopes, free of any other ocular abnormalities were assessed. All were above eighteen years of age. Each patient was subjected to a full clinical examination, refraction, axial length assessment by A scan US and macular thickness determined by spectral domain OCT. Patients were subdivided according to axial length (above and below 26.5mm) into low and high myopes.Results: The study revealed a highly significant negative correlation between increasing axial length and overall average macular thickness. Similarly, there was a significant negative correlation between increasing axial length and macular thickness in all quadrants except in the fovea (no correlation found). Macular thickness was significantly less in high myopes than low myopes except in the fovea (no correlation found). The spherical equivalent was significantly negatively correlated with increasing axial length.Conclusion: In myopes, increasing axial length can be correlated with a decrease in macular thickness except in the foveal region.