In the present study we aimed to assess the effect of fentanyl injected at dural closure in prevention and controlling emergence hypertension.40 normotensive adult patients operated for supratentorial tumors under standard isoflurane anesthesia. At the time of dural closure, the patients were randomly, double blinded assigned to one of two groups (n = 20 each): saline (control), fentanyl (1μg/kg). systolic arterial blood pressure (SAP), diastolic arterial blood pressure (DAP), mean arterial blood pressure (MAP) heart rate (HR) and central venous pressure which were monitored as base line value, after induction, after induction, every 15 minute, at time of dural closure, every 5 minutes till end of surgery, every 15 minute first four hours postoperative and VAS in first two hours.