Radical cystectomy is the standard treatment for patients with invasivebladder cancer and for those with superficial bladder cancer who did notrespond to intravesical therapy (Cheryl et al., 2006, Solsona et al.,2003).Objective: This study aims at evaluation of long-term outcomes, bothfunctional and oncological, in patients treated with radical cystectomyand different types of diversion for invasive bladder cancer.Patients and Methods: This is a retrospective study done in Cairouniversity hospitals and Students' hospital between July 2009 andDecember 2010 included 65 patients, 51 males and 14 females, whomunderwent radical cystectomy with different types of diversions.Results: Erectile dysfunction developed post-operatively in 41 males(80.4%) in non nerve sparing cystectomy, Nocturnal incontinence 41%,Stress incontinence 4.5%, Urge incontinence 4.5%, Totalincontinence2.27% while 21 patients (47.7%) were continent day andnight, Stones developed post-operatively in 2 patients (3.1%), Stomalstenosis developed in 2 patients (12.5% of stomas), Incisional herniadeveloped in 2 patients (3.1%), Ureteric stricture in 2 patients (3.1%),Rediversion was done in one patient (1.5%), Recurrent UTI wasrecorded in 19 cases (29.2% ) 10 cases of orthotopic diversion, 5 cases ofureterocolic, 3 cases of ureterocutaneous and one case of ileal conduit,Uraemia & Dialysis in15.4% of cases, Metastasis was recorded asfollows (Local 1.5%, Distant 18.5% and both 3.1%) and Mortality ratewas 24.6%.Conclusion: Long term follow-up for patients with radical cystectomyand urinary diversion shows high complication and high surgical reinterventionrates. Longer follow-up period for years is needed for radicalcystectomy with urinary diversion techniques to verify causes andprevent complications.