Albuminuria and inflammation predict cardiovascular events. Pentraxin 3, an inflammatory mediator produced by endothelial cells, may have a role in atherogenesis.Our study was conducted on 50 patients with type 2 diabetes mellitus classified into two groups: group I which included 25 type 2 diabetes patients with normal UAE and group II included 25 patients with type 2 diabetes with microalbuminuria and 20 healthy volunteers as a control group. We aimed to measure plasma levels of long pentraxin 3 (PTX3) in patients with type 2 DM with and without microalbuminuria with normal renal function and without overt cardiovascular disease and to evaluate its utility in the early detection of endothelial dysfunction compared to other known markers of endothelial dysfunction (vWF activity and flow dependent arterial dilatation).We found that type 2 diabetic patients with microalbuminuria and normal GFR (stage 1 CKD) have significantly higher PTX-3 concentrations and significantly lower flow mediated dilatation (FMD) than normal individuals and diabetics with normal UAE and normal kidney functions also vWF activity are significantly higher in patients with type 2 diabetes with normal UAER (group I) and in patients with microalbuminuria (group II) compared to controls. There was a significant positive correlation between PTX3 and vWF activity, duration of diabetes, fasting glucose, HbA1c, cholesterol and triglyceride and a significant negative correlation between PTX3 and FMD in all diabetic patients.Conclusion: Our study suggests a link among albuminuria, markers of ED, and development of atherosclerotic complications through pathways that may involve PTX3.