This prospective study included all IDMs who were born at EL Kasr EL-Aini Hospital delivered from May 2010 to September 2011 with exclusion of major congenital anomalies, polycythemia, respiratory distress, sepsis, asphyxia or other clinical manifestations not clearly attributed to hypoglycemia. Blood glucose level was measured immediately after delivery and over 48 hours, taking into consideration maternal data before and during pregnancy and neonatal data including gestational age, sex, body weight, Apgar score, clinical manifestations of hypoglycemia and nutrition of the newborn.Hypoglycemia at 0 hour was more among those born to uncontrolled diabetic mothers, mothers who were on insulin therapy (either GDM-A2 or IDDM) , severe hypoglycemia after birth and on the 1st day of life was more common in neonates that were born to hypertensive, uncontrolled diabetic mothers as well as to mothers on insulin therapy. The mean of glucose values on the 2nd day of life showed improvement for the majority of the neonates.