Aim: this study aims to detect the prevalence of hepatitis C amongEgyptian Pediatric Hemophilic Patients. This will help to follow uphemophiliacs with long-standing HCV infection for early detection of itscomplications as cirrhosis and hepatocellular carcinoma. Also, this can bea start to put patients with HCV infection on therapy.Subjects and methods: This study was conducted on 100hemophilic patients with mean age of 8.62 ± 4.131 years (88 patientswere hemophilia A and 12 were hemophilia B) receiving replacementtherapy. Forty-six of them are following up regularly in the PediatricHematology Clinic, New Children’s Hospital, Cairo University, and 54are following up regularly in Hematology Unit, VACSERA. Allcandidates were subjected to history taking, clinical assessment andlaboratory evaluation including PT, PTT, CT, BT, factor FVIII and FIXactivity, AST, ALT and HCV antibodies, HCV-Ab positive cases weresubjected to HCV PCR.Results: Forty patients were anti-HCV positive (43.2% ofhemophilia A and 16.7% of hemophilia B), 19 of the anti-HCV positivepatients (47.5%) were HCV-RNA positive. Frequency of HCV infectionshowed an increase with older age, decrease coagulation factor activity,increase frequency of bleeds and dose of replacement therapy.Seropositive patients for HCV had higher ALT level, while HCVRNApositive cases showed elevated both ALT and AST.Conclusion: From this study, we can conclude that the frequencyof HCV infection is still high among hemophilic children in Egypt inspiteof improving blood screening for HCV and donor selection. In our studied groups, we identified some risk factors for HCVinfection as increased severity of the disease, increased frequency ofbleeds and doses of replacement therapy.