Background: Breast cancer is the most common type of cancer diagnosed in women excluding skin cancer. In Egypt, breast cancer is the most common cancer among women. Also it has a younger age distribution.The Mammaglobin gene is a member of uteroglobin family. Mammaglobin expression has been observed in breast epithelial cells, its biological role in breast tissue, and by extension in breast cancer, is completely unknown. The particular mechanism mediated by mammaglobin, or whether mammaglobin expression is just a feature of the normal breast epithelial cell that may gets lost during the dedifferentiation process associated with increasing malignant transformation.Aim of work: Study of mammaglobin (MAM) expression in relation to metastatic and non metastatic breast carcinoma and evaluate the ability of using mammaglobin marker as prediction of metastasis.Materials and methods: the studied 30 specimen were subjected to the ordinary H&E staining and immunohistochemical staining for mammaglobin.Results: Correlative studies between mammaglobin expression with different prognostic parameters including the grade and stage of the studied tumors revealed statistically significant correlation between mammaglobin expression and tumor size, grade and lymph node metastasis of breast carcinoma.Conclusions: Increasing mammaglobin intensity seems to be significantly associated with disease progression in breast carcinoma with exception of the tumor grade in which there is an inverse relation mammaglobin expression and low grade tumor and tumor stage that likes to have no relation.The correlation between mammaglobin expression and positive lymph nose metastasis suggested that we can use it as a predictor of tumor metastasis.