Although neutrophils are the most abundant type of white blood cells and form an essential part of the immune system, quantitative abnormalities tack most of researchers work, so it was a deemed of interest to review qualitative abnormalities.This review of disorders of neutrophil number and function will discuss and classification, clinical presentation, important research advances in the field and then provide a clinical diagnostic approach for these category of diseases, and new advances in therapy, prognosis and response.