The incidence of hepatocellular carcinoma (HCC) is rising, and it iscurrently the sixth most common malignancy worldwide. HCC carries apoor prognosis and is the major cause of liver-related death in patients withcompensated cirrhosis.Excess serum iron is common in patients with end-stage liver disease fromaetiologies, such as hepatitis C or alcohol use.Iron overload is one of most important risk factor of hepatocellularcarcinoma in the patients with liver cirrhosis.Assessment of iron studies (serum iron and ferritin) are simple and noninvasive to detect iron overload.The aims of this study were to determine the prevalence of serum ironoverload in patients with end-stage liver disease caused by HCV and toexamine the association of hepatic iron overload with hepatocellularcarcinoma.The study includes 50 HCV related HCC (25 females & 25 males) (group I)and 20 non-HCC liver cirrhosis as controls (group II).Hemoglobin, Total, direct billirubin, Albumin, PC&INR, AST, ALT, ALP,Alpha fetoprotein, Serum iron& ferritin and Abdominal Ultrasound andTriphasic C.T Abdomen were determined.Transaminases are higher in HCC patients than non HCC liver cirrhosis. (Pvalue:o.oo2 for AST) (P- value: 0.0001 for ALT)