Objective: SLE is an autoimmune disease characterized by excessive autoantibody production against ‘self’ antigens and immunocomplex formation, resulting in frequent widespread inflammatory damage to target multiple organ systems. The aim of this study was to determine the association of lymphopenia with the clinical manifestations, serologic abnormalities, disease activity and disease damage as well as drug intake in SLE patients.Methods: thirty female SLE patients with lymphopenia, fifteen female SLE patients without lymphopenia, and ten healthy females with matched age group served as control. All the patients are fulfilling the ACR criteria of SLE. Disease activity was assessed using SLIDAI. Disease damage was assessed with SLICC/DI.Results: Lymphopenia in SLE was found to be associated with lupus nephritis (P=0.023), leucopenia (P=0.004), disease activity (P=0.03) and organ damage (P=0.02) but was not associated with serological abnormalities or with drug intake (P>0.05).Conclusion: lymphopenia was associated with lupus nephritis, leucopenia, disease activity and organ damage.