Neonatal sepsis is one of the major health problemsthroughout the world. Every year an estimated 30 millionsacquire infection & 1-2 millions of these die. A variety of factorscontributed to this serious disease including maternal risk factorsas premature rupture of membrane and others, besides neonatalrisk factors as prematurity and invasive procedures. The aim ofthis study is to compare between septic neonates who havepositive blood culture with those who have negative bloodculture by clinical manifestations, other laboratory tests andoutcome.