Acute asthma is the most common diagnosis in children admitted to hospitals. Among the many genetic variations associated with asthma and asthma phenotypes linked to chromosome 11q13, CC16 is a candidate gene for involvement in the inherited predisposition to asthma. CC16 is the most abundant protein secreted into the airway and it diffuses passively into the serum where it mirrors changes occurring in the lung. It functions as an anti-inflammatory and immunomodulatory agent where it inhibits neutrophil and monocyte chemotaxis, phospholipaseA2 and IFNγ. It has been proposed as a marker for respiratory epithelial injury, non small cell carcinoma and renal tubular dysfunction. CC16 gene has a functional promoter region polymorphism (A38G). The CC16 38A allele is associated with decreased CC16 plasma levels and increased incidence of asthma. This study is an attempt to assess the genetic association of the variants of the CC16 gene in relation to asthma in an Egyptian pediatric population. Forty four asthmatic children (26 males and 18 females), aged 4.5-14 years (mean age 7.73±2.86 years), with mild to severe persistent asthma were chosen. Also 21 age and sex matched children were enrolled as controls. The blood eosinophilic counts, total serum IgE levels, PEFR and were determined for all subjects. Genotyping of exon1 of CC16 gene was done using RFLP-PCR technique. CC16 A38G SNP did not show significant difference in pediatric asthmatic patients compared to the control group. Furthermore, no differences were found in these genotypes as regards atopy, atopy-related phenotypes, IgE level and blood eosinophilic count. However, significantly lower PEFR was found in the AA genotype compared to AG and GG genotypes. These findings may suggest that CC16 A38G polymorphism does not have disease susceptibility potential, but may be related to the severity of the disease.