This study includes a review of references concerning the types of hormones used in replacement therapy. The different regimens used, the routes of administration comparing their advantages and disadvantages, side effects were thoroughly discussed as well as the non hormonal methods used to control menopausal symptoms.Hormone replacement therapy is given either as estrogen alone or combined estrogen and progestagen that may be administered sequentially but has the disadvantage of inducing vaginal bleeding in patient with intact uterus. Therefore, one approach to overcome unwanted vaginal bleeding by giving combined estrogen and progesterone in continuous fashion. Also, androgen could be used in combination with estrogen in certain patients who have sexual problems.Hormone replacement therapy is eventually a natural estrogen. The oral route has been safely used widely by the consequent effect on liver metabolism, leading to variable estrogen concentrations entering the systemic circulation and to undesirable effects on hepatic factors involved thrombosis. This favors the use of an alternative route that delivers estrogen into systemic circulation directly. The transdermal route (TTS) has been shown to be an efficient method of administrating this hormone. The wearing of patches might be more appealing and convenient for some patients. Estraderm can be proved to be cardioprotective and capable of arresting osteoporosis. Other routes of administration are vaginal cream, percutaneous gel or parental route. The dose used with equine estrogen daily is usually 0.625 mg-1.25 mg.The increased risk of endometrial cancer can be prevented by using transdermal progestin therapy or by progesterone releasing intrauterine device. The relationship between breast cancer and estrogen replacement therapy in postmenopausal women is controversial but recent studies concluded that estrogen within the usual dose does not increase breast cancer risk.As for long-term effects, estrogen therapy has proved beneficial in fecal incontinence in postmenopausal women as well as its effects on body mass and bone mass. On balancing the benefits and risk of ERT, the benefits are more than the risks. Therefore, hormone replacement therapy is much recommended.