The essay shows the possibility to use new generation beta-blockers (2nd and 3rd generation beta-blockers) in treatment of heart failure in children, with marked ability of these drugs to improve symptoms and signs of heart failure. Further more there is marked improvement of systolic and diastolic functions and reversed remodeling towards a pseudonormal state.The essay discusses methods of administraction, drug interaction, dosage, side effects and long-term outcome of beta-blocker treatment in heart failure in children.