Epidermolysis bullosa (EB) is a group of inherited bullous disorders characterized by blister formation in response to mechanical trauma, with varying degrees of severity. The dermal-epidermal junction of the skin is a vital area of attachment. Any defects in this junction would lead to fragility of the skin. EB is traditionally classified into three major categories: EB simplex, junctional EB, and dystrophic EB. In addition, a new category termed hemidesmosomal EB is described. There are different classification schemes for EB. The different forms of EB have been linked to mutations in no less than ten genes encoding the major basement membrane zone proteins. EB can be diagnosed both postnatally and prenatally with the recent advances in molecular diagnosis. Current treatment of EB revolves around supportive care and prevention of complications. Potential future therapies for EB include protein and gene therapies.