Nephrotic syndrome (NS) is one of the most common renal disease in childhood. Children suffering from NS are liable to disturbance in the coagulation and fibrinolytic system is one of the most important complications that has been found in many nephrotic patients, it result in a hypercoagulable state with increased risk of thromboembolic problems. In our study we have estimated level of natural inhibitors of coagulation protein C and protein S in 30 nephrotic patient (15 patients steroid sensitive and 15 patients steroid resistant) and 20 healthy children as a control group. Protein S was found significantly deficient in nephrotics compared to healthy control and more obvious in steroid resistant group who are in activity compared with those who are in remission but protein C is insignificantly different in all groups.