Carbon ions – by coating the stents- were suggested to decrease the hypersensitivity mediated in-stent restenosis. This study is an attempt to evaluate the ArthosInert and CarbostentTM in reducing restenosis. We studied 86 high risk lesions divided into three groups; group A, B, and C. Clinical follow-up was performed one and six months after the procedure. Angiographic follow-up was after six months. At 6-months follow-up, there was no statistically significant difference between the 3 groups regarding neither the occurrence of MACE nor binary restenosis rate.