Intercellular adhesion molecule-1 (ICAM, CD.54) is a member of the immunoglobulin super-family of adhesion proteins that participates in the recruitment of eosinophils to asthmatic airways and contributes to the pathogenesis of asthma. The present study aims at comparing the level of serum sICAM-1 in 30 infants with acute asthma and in 10 age and sex matched healthy infants, to find the level significantly higher than that of the control group. The level was found to be significantly lower than that obtained during acute asthma following corticosteroid therapy, so sICAM-1 seems to be a promising serological marker to monitor disease activity in asthma.