Coronary stent placement is increasingly used to improve the early outcome and reduce late restenosis after percutaneous transluminal coronary angioplasty (PTCA). However, a restenosis rate of 20% to 30% after stenting continues to impose a relevant limitation to the management of patients with coronary artery disease. Restenosis is secondary to intimal hyperplasia (IH), therefore studies are directed to determine risk factors relating the process of intimal hyperplasia to the process of restenosis, as further knowledge of risk factors for restenosis after coronary stent placement may help to optimize indications and stent deployment techniques and to guide strategies against this problem.This study was conducted to identify clinical, lesional and procedural factors able to predict restenosis after coronary stenting .The study enrolled 51 patients with 51 lesaions treated successfully with the placement of 55 stents in native coronary arteries. All patients underwent follow-up coronary angiography after 7.66±4.46 months. Angiographic analysis was performed under complete standardized conditions.According to the presence of angiographic in-stent restenosis patients were divided into 2 groups:Group I (ISR) : This group included 22 patients (43.1%) and 22 lesions treated with 25 setnts (45%).Group II (No ISR) : This group included 29 patients (56%) with 29 lesions treated with 30 stents (55%).At follow-up , Focal ISR (< 10 mm ) was detected in 5 patients (22.7%), diffuse ISR (> 10 mm) in 7 patients (31.8%), proliferative ISR in 5 patients (22.7%) and total occlusion in 5 patients (22.7%).In the restenotic group 4 patients were asymptomatic (18.2%), 5 patients had unstable angina (22.7%), 12 patients had stable angina (54.4%) and one patient had QWMI (4.5%). In the non-restenotic group 22 patients were asymptomatic (75.9%), 4 patients had unstable angina (13.8%) and 3 patients had stable angina (10.3%). In the symptomatic patients , 3 were discovered to have critical disease at non-stented sites. By univariate analysis, only one variable (final MLD) was associated with increased risk of binary restenosis (p=0.02).