Twenty patients with splenic focal lesions diagnosed by ultrasonography were included in this study 11 of them were males and 9 females. Their ages ranged from 9 – 73 years with a mean of (35.05 + 17.85). Ultrasound guided aspiration and/or biopsy was performed with histopathological assessment of the specimens. The histopathological examination of the splenic focal lesions revealed that malignant lymphomas were the most common one, fifty percent of the patients were found to have malignant lymphoma, 60% of them were non-Hodgkin’s lymphoma, while the remaining 40% were Hodgkin’s disease. Pyogenic splenic abscesses were present in 15% (N = 3), all of them had leucocytosis with shift to the left. By ultrasonographic examination the lesions were found to be single in (67%) with hypoechoic pattern in (67 %) of the patients. Simple splenic cysts were present in (N = 2 10%) of the cases. By ultrasonographic examination they were single focal lesion (100%) with an anaechoic echopattern. Hydatid disease was present in one of these cases (5%). The remaining diagnosis were solid lesions (metastases) or cystic lesions (hematoma, hemangioma and infarction) each comprising 5%. Ultrasonographic guided needle aspiration was done in all cystic lesions, core biopsy was done in all solid lesions. On comparing both results, sensitivity of core biopsy was 100% while that of aspiration was 89%. Three dimensional ultrasonography was done on 20 patients, the site, number and echogenicity was found to be the same as those detected by two dimensional ultrasonography.Volume of splenic focal lesions was measured by three dimensional ultrasonography and was compared with volume measured by two dimensional ultrasonography. The volume measured by 3 DUS was found to be significantly smaller, P = 0.008. In cystic lesions 40% (n=8) the volume measured by 3 DUS was found to be non significantly smaller, (P > 0.05). In solid lesion 60% (n = 12) the volume measured by 3 DUS was found to be significantly smaller, P = 0.0058. From this study it can be concluded that the volume measured by 3 DUS was significantly smaller than volume measured by 2 DUS.