Systemic sclerosis is a generalized connective tissue disease characterized by sclerotic changes in the skin and multiple internal organ systems. It is associated with prominent alteration of microvascular, autonomic and immune system. Patients with scleroderma were found to have helicobacter pylori infection at a higher prevalence than the general population. Helicobacter pylori might play a role in the development of esophageal and gastric dysfunction.