Asthma is a chronic inflammatory disorder, characterized by recurrent episodes of symptoms of wheezing and chest tightness that are associated with airflow obstruction.Airway inflammation has been considered the primary event leading to airway obstruction and hyperresponsiveness.The principal pathological features of asthma include thickening and disorganization of the tissue of the airway wall with epithelial shedding, deposition of collagen under the basement membrane, hypertrophy / hyperplasia of the smooth muscle, epithelial damage, occlusion of airway by secretion, and infiltration of eosinophils and T-lymphocytes.The introduction of a method which is non-invasive, safe, easy and repeatable for analyzing the cellular and biochemical component of the airway secretions as induced sputum and blood investigation, allowed the direct measurement of airway inflammation.Inhaled steroid are the most effective agents in the management of asthma at present, however, the efficacy of inhaled steroids in suppressing airway inflammation and in modifying the disease remain less well understood.The study was conducted in Kasr El-Aini Hospital, Chest Department.Twenty adult asthmatic patients with different degrees of severity were participated in our study.All patients were subjected to history, clinical examination, C/R, pulmonary function, provocation test, examination of induced sputum and blood for ECP and eosinophils initially and following course of inhaled fluticasone propionate after 4 weeks.Data of all groups were statistically analyzed as shown in tables.