The important circulating manifestations of asphyxia include redistribution of cardiac output to preserve blood flow to more vital organs, but on ongoing asphyxia causes decrease in cerebral blood flow leading to hypoxic-ischemic-encephalopathy (HIE) resulting in CP. T-lymphocytes take a very important role in the immune system and are classified under subsets, but what concernd us in this study was to asses levels of CD4,CD8 and their ratio in asphyxiated newborns in comparison to normal non asphyxiated newborns.It was proved that these ratios are less in asphyxiated newborns than normal newborns, and that is why they are more affected by infections than normal.