Objective: To compare Deep sclerectomy with autologous scleralimplant with deep sclerectomy with Mitomycin C in management ofprimary open angle glaucoma.Materials and methods: 30 eyes of 21 patients with primary open angleglaucoma were divided into two groups (Group A: deep sclerectomy withautologous scleral implant, Group B: deep sclerectomy with MitomycinC). Patients were followed up for 6 months regarding IOP, field of visionand UBM study of the intra-scleral bleb.Results: 12 cases in each group reached the target IOP without use oftreatment (complete success), 3 cases in each group reached the targetIOP with use of anti-glaucoma treatment (qualified success). UBMshowed intra-scleral bleb and intact trabeculo-Descemet membrane in allcases.Conclusion: Both techniques appeared to be safe and effective inlowering IOP in primary open angle glaucoma.