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ADAM33 (a disintegrin and metalloproteinase 33) polymorphism in Egyptian asthmatic childrenthroughout infancy and chidhood

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Pediatrics

Advisors

El-Falaki, Muna M. , Wilson, Manal M. , El-Baz, Muhammad S. , Aly, Dina K.

Authors

Hamed, Dina Husam-El-Din

Accessioned

2017-07-12 06:40:05

Available

2017-07-12 06:40:05

type

M.D. Thesis

Abstract

ADAM33 was the first gene identified by positional cloning to be published as a possiblecandidate for the development of asthma and BHR. The ADAM33 protein is expressed insmooth muscle cells of bronchi and pulmonary fibroblasts, playing a major role in airwayremodelingWe assessed ADAM33 profile in a group of Egyptian asthmatic infants and childrenthrough assessment of 3genetic polymorphism of ADAM33 (V4, T1, T2) with special emphasison the relation of measured parameters to different clinical (severity, smoking, family history,other atopic manifestations) and laboratory data (IgE-peripheral blood eosinophil count) andpulmonary function tests. Sixty asthmatic Children aged 3yr to 12yr and matched control groupof 32 children were recruited for the present study.The genotype distribution for the single nucleotide polymorphism V4, T1, T2 were notsignificantly different among patients and controls.In conclusion, ADAM33 T1, T2, V4 gene polymorphism doesn’t contribute to inheritedpredisposition to asthma in Egyptian children.

Issued

1 Jan 2011

DOI

http://dx.doi.org/10.21473/iknito-space/35037

Details

Type

Thesis

Created At

28 Jan 2023