ADAM33 was the first gene identified by positional cloning to be published as a possiblecandidate for the development of asthma and BHR. The ADAM33 protein is expressed insmooth muscle cells of bronchi and pulmonary fibroblasts, playing a major role in airwayremodelingWe assessed ADAM33 profile in a group of Egyptian asthmatic infants and childrenthrough assessment of 3genetic polymorphism of ADAM33 (V4, T1, T2) with special emphasison the relation of measured parameters to different clinical (severity, smoking, family history,other atopic manifestations) and laboratory data (IgE-peripheral blood eosinophil count) andpulmonary function tests. Sixty asthmatic Children aged 3yr to 12yr and matched control groupof 32 children were recruited for the present study.The genotype distribution for the single nucleotide polymorphism V4, T1, T2 were notsignificantly different among patients and controls.In conclusion, ADAM33 T1, T2, V4 gene polymorphism doesn’t contribute to inheritedpredisposition to asthma in Egyptian children.