Two Health Education Materials were developed (booklet format versusCD-ROM program) the formal as an example for traditional method, however, the latter as an example for innovative school-based curriculum methods that focuses on integrating media, audio, and visuals into classroom settings. It instills critical thinking skills in students as a method of deterring the influence of the multimedia on tobacco use. The development of the material was based on "Socio-Cognitive Theory" SCT and "Trans Theoretical Model" TTM. The study have been implemented with four experimental High Schools at East Nasr City District. The curriculum contains eight lesson plans, which were implemented with 10 classrooms for the 10th grade students. The program was implemented during "Activities" and "Computer" classes in one semester. The curriculum was conducted in 11-week, forty-five minute sessions presented once a week during the 2004-2005 school year. Lessons were divided into two phases; Phase I: Health & cost and decision making process, and Phase II: Peer & Community Advocacy and the "trip of quitting and values". Phase I strategies consisted of raising students’ level of awareness regarding local and national prevalence of tobacco use; educating students about the health and social consequences of tobacco use; teaching students how to analyze and decode media messages; and allowing students to produce their own decision based on cost benefit analysis. Phase II strategies included encouragement of the students inraising values and involving in self help through trip of tobacco quitting andexperience engagement in the community and school tobacco free activities saying no for tobacco and peer educator training. Student's knowledge, attitude, and behavior were assessed by standard questionnaires which were adapted to suite the age and developmental stage of the students. The anonymous questionnaires were administered one week before the implementation of the curriculum (pre-test) and one week immediately after the completion of the curriculum (post-test). Two followup sessions were conducted at six-month and one-year time periods. The primary goal of this research project is to evaluate the relative effectiveness of an anti-tobacco Multimedia Health Education Curriculum using (CAL) among a selected group of high school students. Secondary goals include: (1) to decrease the prevalence of tobacco use among students; and (2) to decrease the number of studentswho believe tobacco use is acceptable by strategically applying normative education. The participants were divided into 4 groups, 1st group received pre- post testwithout intervention, 2nd group received booklet format as traditional education,3rd II group received CD-Rom,4th group received both CD-Rom plus booklet. A pre-posttest quasi-experimental design was conducted to evaluate the effectiveness of the CD-Rom among first year secondary school students. Change in knowledge, attitude, and behavior among 400 students who participated in the study. From 2004 through 2005. A total of 396 students participated in the study. The school response rate was 100% (sample of 4 schools) were surveyed, the student response rate was 99% and the overall response rate was 99%. In addition, a qualitative usability study wasconducted among students using focus groups.Research results has shown that (CAL) is an effective tool for delivery of aprevention program due to its accessibility and availability in most schools. Elements of interactivity and expert-trusted guidance were identified as appealing to most participating students. In addition, the use of pictures and graphics in conjunction with text proved to be useful in reaching students with varied learning styles.Changes in self perception, attitude, and knowledge about tobacco smokingwere assessed. Results indicate significant increase in knowledge, attainment of more positive attitude and behavior change in ( CD-Rom and Booklet group) which demonstrate a critical step in the rational development of new school-based prevention strategies. In addition, self efficacy for those exposed to CD-Rom in groups 3 and 4 compared with other groups. Also, for those exposed to the CD, an increase in the interest for the learning process was observed compared to other groups.This study suggests that appropriately-designed CAL courseware can be aneffective instructional method in the classroom setting specially when combined with a printed format, and that the health educational application of it has the potential to be efficacious. Hopefully, this study will serve as a catalyst for further research into the use of CAL courseware in the Health Education at School.