More sensitive and rapid tests for diagnosis of typhoid fever include dip-S-tick and typhidot tests. PCR of blood samples is also a sensitive method for its diagnosis. Also, ELISA or dip-S-tick or BrucellaCapt tests are useful rapid and sensitive tests for dignosis of Brucella. PCR appears to be useful in diagnosis of acute brucellosis. The use of dip-S-tick and ELISA tests for diagnosis of Leptospira was found to be specific, fast and easy. PCR has a clear advantage in its diagnosis. IFA test is the most widely used in diagnosis of coxiella burnetti also PCR is a rapid and sensitive method. Chronic Q fever endocarditis is also diagnosed by IFA with IgG titer >1/800 in Egypt.